In this present study hydrazone derivative of 5-chloro-2-acetylbenzofuran was condensed with different substituted\r\naromatic aldehydes to form respective schiff bases (5a-h) then cyclised with chloroacetylchloride in presence of triethylamine to\r\nyield the corresponding 2-azetidinones (6a-h). Structures of synthesized compounds are confirmed by physical and spectral\r\nanalysis. The synthesized 2-azetidinones (6a-h) were evaluated for their antimicrobial activity against Staphylococcus aureus\r\n(NCIM-2079), Bacillus subtilis (NCIM-2063), Escherichia coli (NCIM-2068), Proteus vulgaris (NCIM-2027), Aspergillus niger\r\n(ATCC-6275) and Candida tropicalis (ATCC-1369) using ampicillin and fluconzazole as standard drugs. All the compounds have\r\nshown moderate antimicrobial activities.
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